| Characteristic | Description |
|---|---|
| Active Ingredients | Sildenafil 100 mg, Fluoxetine 40 mg |
| Formulation | Tablets |
| Indications | Erectile dysfunction, Premature ejaculation |
| Administration Route | Oral |
| Recommended Dosage | Once daily, as needed |
| Learn More | |
Pharmacokinetics
Malegra FXT combines Sildenafil 100 mg with Fluoxetine 40 mg. It addresses erectile dysfunction and premature ejaculation. Sildenafil inhibits phosphodiesterase type 5 (PDE5), enhancing erectile function. Fluoxetine, a selective serotonin reuptake inhibitor, helps delay ejaculation.
Upon oral administration, Sildenafil reaches peak plasma levels in approximately one hour. Its absorption can be delayed by a high-fat meal. Fluoxetine achieves peak concentrations within 6 to 8 hours. It exhibits a longer half-life, sustaining its therapeutic effects. The combination of these agents offers a dual approach.
The metabolic pathway of Sildenafil primarily involves hepatic cytochrome P450 enzymes. Fluoxetine also undergoes hepatic metabolism. Both substances exhibit extensive protein binding. Their metabolites are excreted predominantly via the urine.
Areas of Use
Malegra FXT is utilized for sexual health issues in men. Its dual-action formula enhances erectile response and prolongs ejaculatory latency. The inclusion of Sildenafil 100 mg addresses erectile dysfunction by facilitating vasodilation in penile tissues. Fluoxetine 40 mg extends the time to ejaculation, reducing anxiety related to premature climax.
The combination is suitable for patients who experience these conditions concurrently. It offers a simplified regimen by combining two therapeutic actions. However, patients should consult healthcare providers to confirm suitability.
Malegra FXT Contraindications
Malegra FXT is contraindicated in patients with hypersensitivity to its components. It should not be taken by those using nitrates or nitric oxide donors. These substances can lead to severe hypotension when combined with Sildenafil. It is also unsuitable for individuals with severe hepatic impairment or retinal disorders.
Patients with a history of cardiovascular conditions should exercise caution. The combination of Sildenafil 100 mg with other vasodilators or serotoninergic drugs may pose risks. More details on safety concerns are available in scientific literature.
Malegra FXT Interactions
Drug interactions may alter the efficacy of Malegra FXT. Concomitant use with CYP3A4 inhibitors can increase Sildenafil plasma levels. This raises the risk of adverse effects. Fluoxetine, as a CYP2D6 inhibitor, can interact with other serotoninergic drugs.
- Alcohol: May enhance side effects such as dizziness.
- Antidepressants: Potential for serotonin syndrome with SSRIs.
- Antihypertensives: Risk of additive blood pressure-lowering effects.
Malegra FXT Signs and Symptoms of Overdose
Overdose of Malegra FXT requires immediate medical attention. Symptoms may include severe hypotension, syncope, and prolonged erection. Tachycardia and nausea may also occur. Gastrointestinal decontamination should be performed if ingestion is recent.
Monitoring cardiovascular status is crucial in overdose cases. Supportive treatment and symptomatic management are often necessary. Severe overdose may lead to complications requiring hospitalization.
Malegra FXT for Sale Online
Malegra FXT can be sourced from various online platforms. Customers should prioritize purchasing from licensed pharmacies. Ensuring product authenticity and safety is paramount. It is advisable to check the legitimacy of the online source.
Online availability facilitates access to Malegra FXT, providing convenience for patients. However, consulting healthcare professionals before usage is essential to prevent adverse outcomes and ensure optimal therapeutic benefit.
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